Le Sereno Hotel's staff is widely praised for being friendly, helpful and providing great service. The concierge is especially lauded for being excellent and flirting generously with older guests. The staff mostly speaks English and is patient with guests who struggle with French. Guests also note that the housekeeping is great and the 24-hour valet service is very convenient. Overall, the staff is seen as the best part of the hotel, creating a warm atmosphere that makes their guests feel welcome. However, there were a few remarks about terrible service, but they were the exception rather than the norm.